Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HTR3A | P46098 | 1/20 | 0.43 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777229 | 1.00 | TMEM97 (0.43) | TMEM97SIGMAR1HTR3AHTR4MEN1 | |
| SCHEMBL2777224 | 1.00 | TMEM97 (0.43) | TMEM97SIGMAR1HTR3AHTR4MEN1 | |
| SCHEMBL2775584 | 0.85 | MEN1 (0.53) | MEN1KMT2AATMGAAALDH1A1 | |
| SCHEMBL2775579 | 0.85 | MEN1 (0.53) | MEN1KMT2AATMGAAALDH1A1 | |
| SCHEMBL2775582 | 0.85 | MEN1 (0.53) | MEN1KMT2AATMGAAALDH1A1 | |
| SCHEMBL2776224 | 0.84 | CNR2 (0.42) | ALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL2776229 | 0.84 | CNR2 (0.42) | ALDH1A1MAPTHTTSMN1; SMN2 | |
| SCHEMBL2778819 | 0.80 | ERCC1 (0.39) | ALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL2778821 | 0.80 | ERCC1 (0.39) | ALDH1A1LMNASMN1; SMN2CYP1A2 | |
| SCHEMBL2778824 | 0.80 | ERCC1 (0.39) | ALDH1A1LMNASMN1; SMN2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7906541-B2 | Process to prepare new substituted 1H-benzo[d]imidazol-2(3H)-ones, new intermediates and their use as BACE 1 inhibitors | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2011-03-15 | — | — | US | claimed |
| WO-2010052670-A1 | PROCESS TO PREPARE NEW SUBSTITUTED 1H-BENZO [d] IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-14 | — | — | WO | claimed |
| US-20100120880-A1 | PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-13 | — | — | US | claimed |
| US-7906541-B2 | Process to prepare new substituted 1H-benzo[d]imidazol-2(3H)-ones, new intermediates and their use as BACE 1 inhibitors | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2011-03-15 | — | — | US | disclosed |
| WO-2010052670-A1 | PROCESS TO PREPARE NEW SUBSTITUTED 1H-BENZO [d] IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-14 | — | — | WO | disclosed |
| US-20100120880-A1 | PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | UNIVERSITE PAUL CEZANNE-AIX MARSEILLE III (FR) | 2010-05-13 | — | — | US | disclosed |
| EP-2184276-A1 | Process to prepare new substituted 1H-Benzo(d) imidazol-2(3h)-Ones, New intermediates and their use as bace 1 inhibitors | UNIVERSITE PAUL CEZANNE AIX-MARSEILLE III (FR) | 2010-05-12 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120880-A1 | PROCESS TO PREPARE NEW SUBSITUTED 1H-BENZO[d]IMIDAZOL-2(3H)-ONES, NEW INTERMEDIATES AND THEIR USE AS BACE 1 INHIBITORS | BACE1, BACE2, PSEN1 | TMEM97 935/4885SIGMAR1 2392/4885HTR3A 727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.