Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKB | Q96GD4 | 3/20 | 0.53 |
| ▸ | AURKA | O14965 | 2/20 | 0.53 |
| ▸ | INCENP | Q9NQS7 | 2/20 | 0.53 |
| ▸ | TPX2 | Q9ULW0 | 2/20 | 0.53 |
| ▸ | CIT | O14578 | 4/20 | 0.47 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 9/20 | 0.43 |
| ▸ | JAK1 | P23458 | 8/20 | 0.43 |
| ▸ | JAK3 | P52333 | 4/20 | 0.42 |
| ▸ | TYK2 | P29597 | 1/20 | 0.42 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 2/20 | 0.40 |
| ▸ | CHUK | O15111 | 2/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29540620 | 0.84 | GRM4 (0.62) | AURKBAURKAINCENPTPX2CIT | |
| SCHEMBL101789 | 0.84 | GRM4 (0.62) | AURKBAURKAINCENPTPX2CIT | |
| SCHEMBL100470 | 0.83 | AURKA (0.54) | AURKBAURKAINCENPTPX2CIT | |
| SCHEMBL29540505 | 0.83 | AURKA (0.54) | AURKBAURKAINCENPTPX2CIT | |
| SCHEMBL99403 | 0.82 | AURKB (0.55) | AURKBAURKAINCENPTPX2CIT | |
| SCHEMBL100507 | 0.82 | AURKB (0.55) | AURKBAURKAINCENPTPX2CIT | |
| SCHEMBL29540831 | 0.82 | AURKB (0.55) | AURKBAURKAINCENPTPX2CIT | |
| Trifluoroacetic Acid SCHEMBL4087373 | 0.78 | GRM4 (0.53) | AURKBAURKAINCENPTPX2CIT | |
| SCHEMBL28338421 | 0.78 | AURKB (0.56) | AURKBAURKAINCENPTPX2CIT | |
| SCHEMBL14500069 | 0.77 | AURKB (0.63) | AURKBAURKAINCENPTPX2CIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103254190-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2013-08-21 | — | — | CN | claimed |
| CN-103214484-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP A DELAWARE CORP | 2013-07-24 | — | — | CN | claimed |
| CN-103214483-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2013-07-24 | — | — | CN | claimed |
| CN-101448826-A | Heteroaryl substituted pyrrolo [2 ] as janus kinase inhibitors | INCYTE CORP (US) | 2009-06-03 | — | — | CN | claimed |