Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 3/20 | 0.71 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.57 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.57 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.57 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.57 |
| ▸ | MKNK1 | Q9BUB5 | 9/20 | 0.53 |
| ▸ | CCNK | O75909 | 1/20 | 0.53 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.50 |
| ▸ | BRD4 | O60885 | 1/20 | 0.50 |
| ▸ | MKNK2 | Q9HBH9 | 3/20 | 0.49 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.47 |
| ▸ | CIT | O14578 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100305 | 0.84 | GRM4 (1.00) | GRM4KCNH2AURKAAURKBINCENP | |
| SCHEMBL101660 | 0.82 | GRM4 (0.70) | GRM4KCNH2AURKAAURKBINCENP | |
| SCHEMBL857153 | 0.81 | NUDT1 (0.64) | AURKAAURKBINCENPTPX2CCNK | |
| SCHEMBL29540920 | 0.81 | GRM4 (0.72) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL100506 | 0.81 | GRM4 (0.72) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL100070 | 0.79 | GRM4 (0.66) | GRM4KCNH2AURKAAURKBINCENP | |
| SCHEMBL29540638 | 0.79 | GRM4 (0.66) | GRM4KCNH2AURKAAURKBINCENP | |
| SCHEMBL100436 | 0.78 | GRM4 (0.68) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL29540575 | 0.78 | GRM4 (0.68) | GRM4AURKAAURKBINCENPTPX2 | |
| SCHEMBL6123302 | 0.77 | GRM4 (0.77) | GRM4KCNH2AURKAAURKBINCENP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103254190-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2013-08-21 | — | — | CN | claimed |
| CN-103214484-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP A DELAWARE CORP | 2013-07-24 | — | — | CN | claimed |
| CN-103214483-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2013-07-24 | — | — | CN | claimed |
| CN-101448826-A | Heteroaryl substituted pyrrolo [2 ] as janus kinase inhibitors | INCYTE CORP (US) | 2009-06-03 | — | — | CN | claimed |