Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PRKCI | P41743 | 10/20 | 0.41 |
| ▸ | PRKCA | P17252 | 7/20 | 0.41 |
| ▸ | PRKCE | Q02156 | 7/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.40 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27762526 | 0.80 | BRD4 (0.44) | BRD4PRKCIPRKCAPRKCECLK4 | |
| SCHEMBL29540736 | 0.80 | CYP2D6 (0.44) | BRD4CYP2D6CLK4CDK5CCNB2 | |
| SCHEMBL101287 | 0.80 | CYP2D6 (0.44) | BRD4CYP2D6CLK4CDK5CCNB2 | |
| SCHEMBL100468 | 0.79 | JAK2 (0.52) | PRKCICLK4CDK5NUDT1CCNK | |
| SCHEMBL30663353 | 0.79 | JAK2 (0.52) | PRKCICLK4CDK5NUDT1CCNK | |
| SCHEMBL858602 | 0.76 | BRD4 (0.62) | BRD4PRKCICLK4CDK5CCNB2 | |
| Trifluoroacetic Acid SCHEMBL4082706 | 0.72 | CYP2D6 (0.44) | PRKCIPRKCAPRKCECYP2D6HSD17B10 | |
| SCHEMBL29541300 | 0.71 | PRKCI (0.56) | PRKCICLK4CDK5GSK3BNUDT1 | |
| SCHEMBL98619 | 0.71 | PRKCI (0.56) | PRKCICLK4CDK5GSK3BNUDT1 | |
| SCHEMBL100846 | 0.70 | GRM5 (0.43) | BRD4PRKCICYP3A4CYP2D6CLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103254190-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2013-08-21 | — | — | CN | claimed |
| CN-103214484-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP A DELAWARE CORP | 2013-07-24 | — | — | CN | claimed |
| CN-103214483-A | Heteroaryl substituted pyrrolo[2,3-b]pyridines and pyrrolo[2,3-b]pyrimidines as janus kinase inhibitors | INCYTE CORP | 2013-07-24 | — | — | CN | claimed |
| CN-101448826-A | Heteroaryl substituted pyrrolo [2 ] as janus kinase inhibitors | INCYTE CORP (US) | 2009-06-03 | — | — | CN | claimed |