Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.52 |
| ▸ | IKBKB | O14920 | 1/20 | 0.52 |
| ▸ | CHUK | O15111 | 1/20 | 0.52 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.52 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.52 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | CSF1R | P07333 | 1/20 | 0.52 |
| ▸ | RET | P07949 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 1/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.52 |
| ▸ | PRKACA | P17612 | 1/20 | 0.52 |
| ▸ | FLT1 | P17948 | 1/20 | 0.52 |
| ▸ | LTK | P29376 | 1/20 | 0.52 |
| ▸ | GRK5 | P34947 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.52 |
| ▸ | CDK8 | P49336 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL100468 | 1.00 | JAK2 (0.52) | JAK2IKBKBCHUKDAPK3PRKD3 | |
| SCHEMBL101287 | 0.84 | CYP2D6 (0.44) | CDK5ROCK1DYRK1ALRRK2CLK4 | |
| SCHEMBL29540736 | 0.84 | CYP2D6 (0.44) | CDK5ROCK1DYRK1ALRRK2CLK4 | |
| SCHEMBL100846 | 0.84 | GRM5 (0.43) | JAK2IKBKBCHUKDAPK3PRKD3 | |
| SCHEMBL29540698 | 0.84 | GRM5 (0.43) | JAK2IKBKBCHUKDAPK3PRKD3 | |
| SCHEMBL27762540 | 0.79 | BRD4 (0.46) | JAK2IKBKBCHUKDAPK3PRKD3 | |
| Trifluoroacetic Acid SCHEMBL4097362 | 0.78 | SGK1 (0.40) | JAK2IKBKBCHUKDAPK3PRKD3 | |
| Trifluoroacetic Acid SCHEMBL4082706 | 0.78 | CYP2D6 (0.44) | ROCK1PRKCIRAB9A | |
| SCHEMBL29541300 | 0.77 | PRKCI (0.56) | JAK2IKBKBCHUKDAPK3PRKD3 | |
| SCHEMBL98619 | 0.77 | PRKCI (0.56) | JAK2IKBKBCHUKDAPK3PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3838903-B1 | PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AS JANUS KINASE INHIBITOR | INCYTE HOLDINGS CORP (US) | 2023-11-22 | — | — | EP | disclosed |