Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ASH1L | Q9NR48 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27785230 | 0.81 | KIF11 (0.40) | KIF11KMT2AMEN1ALDH1A1KDM4E | |
| SCHEMBL27785233 | 0.81 | PLG (0.33) | PARP1ALDH1A1KDM4EHSD17B10HPGD | |
| SCHEMBL27830617 | 0.80 | KDM4E (0.38) | RAB9AJAK2KMT2AMEN1ALDH1A1 | |
| SCHEMBL27785243 | 0.79 | AR (0.39) | PARP1JAK2ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL27763401 | 0.79 | PIM3 (0.36) | GAA | |
| SCHEMBL27763420 | 0.79 | KIF11 (0.43) | KIF11PARP1RAB9AKDM4E | |
| SCHEMBL30014455 | 0.78 | KIF11 (0.57) | KIF11PARP1RAB9AJAK2DYRK1A | |
| SCHEMBL3217015 | 0.78 | KIF11 (0.57) | KIF11PARP1RAB9AJAK2DYRK1A | |
| SCHEMBL27785248 | 0.77 | EIF4A3 (0.34) | KIF11KMT2AMEN1 | |
| SCHEMBL27763426 | 0.77 | BTK (0.37) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101583598-B | Novel indole derivative having inhibitory activity on i kappa b kinase | SANTEN PHARMACEUTICAL CO LTD | 2012-09-12 | — | — | CN | claimed |
| CN-101583598-A | Novel indole derivative having inhibitory activity on i kappa b kinase ss | SANTEN PHARMACEUTICAL CO LTD (JP) | 2009-11-18 | — | — | CN | claimed |
| CN-101583598-B | Novel indole derivative having inhibitory activity on i kappa b kinase | SANTEN PHARMACEUTICAL CO LTD | 2012-09-12 | — | — | CN | disclosed |
| CN-101583598-A | Novel indole derivative having inhibitory activity on i kappa b kinase ss | SANTEN PHARMACEUTICAL CO LTD (JP) | 2009-11-18 | — | — | CN | disclosed |