Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | TTK | P33981 | 1/20 | 0.54 |
| ▸ | CHUK | O15111 | 1/20 | 0.54 |
| ▸ | ICOSLG | O75144 | 1/20 | 0.54 |
| ▸ | ICOS | Q9Y6W8 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.50 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL277775 | 0.91 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL26066148 | 0.85 | SNCA (0.60) | KMT2AMEN1SMN1; SMN2TSHRCHUK | |
| SCHEMBL29278946 | 0.84 | MEN1 (0.76) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL259603 | 0.82 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL18343125 | 0.81 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL5922458 | 0.81 | KDM4D (0.60) | KMT2ARAB9APOLBNPC1HTT | |
| SCHEMBL273817 | 0.81 | POLB (0.47) | KMT2AMEN1SMN1; SMN2POLBHTT | |
| SCHEMBL259609 | 0.80 | ALDH1A1 (0.62) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL259608 | 0.79 | ALDH1A1 (0.61) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR | |
| SCHEMBL13319566 | 0.77 | MEN1 (0.65) | ALDH1A1KMT2AMEN1SMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8067586-B2 | Fused heteroaryl derivatives | ASTELLAS PHARMA INC. (JP) | 2011-11-29 | — | — | US | disclosed |
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | HAYAKAWA MASAHIKO | 2010-06-03 | — | — | US | disclosed |
| US-20100137585-A1 | FUSED HETEROARYL DERIVATIVES | HAYAKAWA MASAHIKO | 2010-06-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137584-A1 | FUSED HETEROARYL DERIVATIVES | PIK3CD, PIK3R3, PIK3C2A | ALDH1A1 4428/4885KMT2A 1722/4885MEN1 3330/4885 |
| US-20100137585-A1 | FUSED HETEROARYL DERIVATIVES | PIK3CD, PIK3R3, PIK3C2A | ALDH1A1 4428/4885KMT2A 1722/4885MEN1 3330/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.