Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.51 |
| ▸ | HTR2A | P28223 | 3/20 | 0.51 |
| ▸ | HTR2B | P41595 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27765410 | 0.79 | HTR2C (0.51) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL4880157 | 0.75 | HTR2C (0.52) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL20558927 | 0.75 | HTR2C (0.59) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL10253774 | 0.75 | HTR2C (0.59) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL3710603 | 0.71 | HTR2C (0.54) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL26773976 | 0.71 | HTR2C (0.56) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL26773979 | 0.71 | HTR2C (0.56) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL26773982 | 0.71 | HTR2C (0.56) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL26773980 | 0.71 | HTR2C (0.56) | HTR2CHTR2AHTR2BKDM4EALDH1A1 | |
| SCHEMBL26773978 | 0.71 | HTR2C (0.56) | HTR2CHTR2AHTR2BKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101605791-A | 6-benzyl-2, 3,4, 7-tetrahydro-indolo [2, 3-c ] quinoline compounds useful as PDE5 inhibitors | STEFFEN WEINBRENNER (DE) | 2009-12-16 | — | — | CN | disclosed |