Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | HTT | P42858 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | HPGD | P15428 | 2/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.54 |
| ▸ | RELA | Q04206 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
| ▸ | GFER | P55789 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL155616 | 0.89 | RECQL (0.62) | MAPTHTTALDH1A1HPGDRAB9A | |
| SCHEMBL9528793 | 0.85 | KDM4E (0.63) | MAPTHTTALDH1A1HPGDRAB9A | |
| SCHEMBL27852868 | 0.84 | HTT (0.60) | MAPTHTTALDH1A1HPGDGAA | |
| SCHEMBL956179 | 0.83 | ALDH1A1 (0.64) | MAPTHTTALDH1A1HPGDRAB9A | |
| SCHEMBL996929 | 0.80 | GFER (0.66) | MAPTHTTALDH1A1HPGDGAA | |
| SCHEMBL16991022 | 0.78 | HPGD (0.55) | MAPTHTTALDH1A1HPGDRAB9A | |
| SCHEMBL10076588 | 0.77 | RECQL (0.68) | MAPTHTTALDH1A1HPGDRAB9A | |
| SCHEMBL7056572 | 0.77 | ALDH1A1 (0.52) | MAPTALDH1A1RAB9AKDM4EPOLB | |
| SCHEMBL19626644 | 0.76 | HPGD (0.65) | MAPTHTTALDH1A1HPGDRAB9A | |
| SCHEMBL13475977 | 0.75 | GRM5 (0.54) | MAPTHTTALDH1A1HPGDRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102015675-B | Chlorothiophene-amides as inhibitors of coagulation factors Xa and thrombin | SANOFI AVENTIS | 2014-07-02 | — | — | CN | disclosed |
| CN-101454301-A | Thiazole derivatives | HOFFMANN LA ROCHE (CH) | 2009-06-10 | — | — | CN | disclosed |