Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 7/20 | 0.51 |
| ▸ | PARP15 | Q460N3 | 5/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.51 |
| ▸ | TNKS | O95271 | 1/20 | 0.51 |
| ▸ | PARP2 | Q9UGN5 | 5/20 | 0.49 |
| ▸ | PARP10 | Q53GL7 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.42 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.41 |
| ▸ | ERCC5 | P28715 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.41 |
| ▸ | DAO | P14920 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5113224 | 0.79 | PARP15 (0.48) | TNKS2PARP15PARP1TNKSPARP2 | |
| SCHEMBL1244218 | 0.78 | TNKS2 (0.43) | TNKS2PARP15PARP1TNKSPARP2 | |
| SCHEMBL27703596 | 0.74 | PDPK1 (0.46) | PARP1ALDH1A1ERCC5FEN1DAO | |
| SCHEMBL5104219 | 0.71 | PARP15 (0.47) | TNKS2PARP15PARP1TNKSPARP2 | |
| SCHEMBL25369756 | 0.71 | TNKS2 (0.51) | TNKS2PARP15PARP1TNKSPARP2 | |
| SCHEMBL13997679 | 0.70 | KDM4E (0.72) | TNKS2PARP15PARP1TNKSMEN1 | |
| SCHEMBL1549073 | 0.69 | TNKS2 (0.67) | TNKS2PARP15PARP1TNKSPARP2 | |
| SCHEMBL29478203 | 0.68 | TNKS2 (1.00) | TNKS2PARP15PARP1TNKSPARP2 | |
| SCHEMBL422013 | 0.68 | TNKS2 (1.00) | TNKS2PARP15PARP1TNKSPARP2 | |
| SCHEMBL4154430 | 0.67 | EGLN1 (0.47) | TNKS2PARP15PARP1TNKSPARP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466681-A | Tumor necrosis factor alpha inhibitors and their use in the treatment of human diseases | AVANIR PHARMACEUTICALS (US) | 2009-06-24 | — | — | CN | disclosed |