Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 8/20 | 0.78 |
| ▸ | MEN1 | O00255 | 1/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.71 |
| ▸ | PLAU | P00749 | 1/20 | 0.69 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.69 |
| ▸ | ESR1 | P03372 | 1/20 | 0.65 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | RAB9A | P51151 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | FABP6 | P51161 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2243148 | 0.97 | CHEK2 (0.80) | CHEK2MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL3178116 | 0.91 | CHEK2 (0.78) | CHEK2KMT2AHDAC3HDAC1HDAC8 | |
| SCHEMBL5675969 | 0.88 | CHEK2 (0.81) | CHEK2MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL19982678 | 0.88 | CHEK2 (0.74) | CHEK2MEN1KMT2AHDAC3HDAC1 | |
| SCHEMBL19994499 | 0.88 | CHEK2 (0.79) | CHEK2MEN1KMT2AESR1PKM | |
| SCHEMBL19994652 | 0.88 | CHEK2 (0.79) | CHEK2MEN1KMT2AESR1PKM | |
| SCHEMBL9308135 | 0.86 | CHEK2 (0.68) | CHEK2NR4A2 | |
| SCHEMBL5679988 | 0.86 | CHEK2 (1.00) | CHEK2 | |
| SCHEMBL18237054 | 0.85 | HDAC6 (0.95) | CHEK2HDAC3HDAC1HDAC8HDAC6 | |
| SCHEMBL34467256 | 0.85 | CHEK2 (0.64) | CHEK2MEN1KMT2AHDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101420950-B | Treatment of duchenne muscular dystrophy | SUMMIT CORP PLC | 2012-04-18 | — | — | CN | disclosed |
| CN-101678107-A | Pharmaceutical composition for treating Duchenne muscular dystrophy | SUMMIT CORP PLC | 2010-03-24 | — | — | CN | disclosed |
| CN-101420950-A | Treatment of Duchenne muscular dystrophy | SUMMIT CORP PLC (GB) | 2009-04-29 | — | — | CN | disclosed |