Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 5/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HPN | P05981 | 1/20 | 0.34 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.34 |
| ▸ | CDC7 | O00311 | 1/20 | 0.34 |
| ▸ | PLK4 | O00444 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27909732 | 0.89 | JAK2 (0.44) | PIM1MAPTJAK2BRD4KDM4E | |
| SCHEMBL27767419 | 0.85 | IDO1 (0.39) | IDO1MAPTCA1CA2BRD4 | |
| SCHEMBL27789086 | 0.85 | BRD4 (0.44) | PIM1MAPTBRD4KDM4EALDH1A1 | |
| SCHEMBL27892770 | 0.81 | MEN1 (0.43) | JAK2BRD4ALDH1A1SLC9A1MAPK1 | |
| SCHEMBL27767424 | 0.80 | IKBKB (0.43) | MAPTJAK2BRD4KDM4ECDC7 | |
| SCHEMBL27767420 | 0.80 | GCGR (0.40) | MAPTJAK2BRD4ALDH1A1GAA | |
| SCHEMBL27788983 | 0.79 | PARP1 (0.44) | JAK2BRD4CDC7CDK2MEN1 | |
| SCHEMBL27789042 | 0.77 | CASP1 (0.45) | JAK2BRD4ALDH1A1MAPK1CDC7 | |
| SCHEMBL27788861 | 0.76 | BRD4 (0.41) | BRD4CDC7CDK2 | |
| SCHEMBL2200770 | 0.74 | P2RX1 (0.44) | PIM1IDO1MAPTPKMCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101622229-B | Pyrrole derivatives having ureido and aminocarbonyl groups as substituents | SANTEN PHARMACEUTICAL CO LTD | 2013-02-27 | — | — | CN | claimed |
| CN-101622229-A | Novel pyrrole derivatives having ureido group and aminocarbonyl group as substituents | SANTEN PHARMACEUTICAL CO LTD | 2010-01-06 | — | — | CN | claimed |
| CN-101622229-B | Pyrrole derivatives having ureido and aminocarbonyl groups as substituents | SANTEN PHARMACEUTICAL CO LTD | 2013-02-27 | — | — | CN | disclosed |
| CN-101622229-A | Novel pyrrole derivatives having ureido group and aminocarbonyl group as substituents | SANTEN PHARMACEUTICAL CO LTD | 2010-01-06 | — | — | CN | disclosed |