Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 11/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.50 |
| ▸ | MTOR | P42345 | 1/20 | 0.49 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.43 |
| ▸ | IL2 | P60568 | 2/20 | 0.43 |
| ▸ | TLR9 | Q9NR96 | 4/20 | 0.42 |
| ▸ | PGK1 | P00558 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL324652 | 0.97 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL27767931 | 0.92 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL27767855 | 0.90 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL182761 | 0.89 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL182904 | 0.86 | PIK3CD (0.57) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL182858 | 0.82 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL182816 | 0.80 | MAP4K1 (0.61) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| Tert-Butyl Formate SCHEMBL27767933 | 0.80 | MAP4K1 (0.53) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL28776661 | 0.79 | PIK3CD (0.51) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 | |
| SCHEMBL182675 | 0.78 | PIK3CD (0.52) | PIK3CDPIK3CAPIK3CBPIK3CGKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049502-B1 | 2,4-SUBSTITUTED QUINAZOLINES AS LIPID KINASE INHIBITORS | NOVARTIS AG (CH) | 2012-01-04 | — | — | EP | claimed |