Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVRL1 | P37023 | 7/20 | 0.60 |
| ▸ | MERTK | Q12866 | 1/20 | 0.47 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 5/20 | 0.42 |
| ▸ | KIT | P10721 | 3/20 | 0.42 |
| ▸ | FLT3 | P36888 | 3/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.40 |
| ▸ | FRK | P42685 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.40 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.40 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.40 |
| ▸ | MAP4K2 | Q12851 | 1/20 | 0.40 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.40 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.40 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL58299 | 0.92 | ACVRL1 (0.62) | ACVRL1MERTKNTRK2NTRK1KDR | |
| SCHEMBL58575 | 0.91 | ACVRL1 (0.60) | ACVRL1MERTKNTRK2NTRK1KDR | |
| SCHEMBL57964 | 0.91 | ACVRL1 (0.60) | ACVRL1MERTKNTRK2NTRK1KDR | |
| Hydrochloric Acid SCHEMBL27768114 | 0.90 | ACVRL1 (0.63) | ACVRL1MERTKNTRK2NTRK1KDR | |
| SCHEMBL59355 | 0.89 | ACVRL1 (0.58) | ACVRL1MERTKNTRK2NTRK1KDR | |
| SCHEMBL59318 | 0.89 | ACVRL1 (0.58) | ACVRL1MERTKNTRK2NTRK1KDR | |
| SCHEMBL27747161 | 0.89 | ACVRL1 (0.60) | ACVRL1MERTKNTRK2NTRK1KDR | |
| SCHEMBL58540 | 0.86 | ACVRL1 (0.57) | ACVRL1MERTKKDRFLT3RET | |
| SCHEMBL59409 | 0.85 | ACVRL1 (0.55) | ACVRL1MERTKKDRKITFLT3 | |
| SCHEMBL59260 | 0.85 | ACVRL1 (0.57) | ACVRL1MERTKNTRK2NTRK1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101466710-B | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC | 2013-05-29 | — | — | CN | disclosed |
| CN-101466710-A | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2009-06-24 | — | — | CN | disclosed |