Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.34 |
| ▸ | DNM1L | O00429 | 2/20 | 0.33 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.32 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28784616 | 0.93 | GPR119 (0.39) | GPR119SMN1; SMN2KMT2AAOC3SLC6A3 | |
| SCHEMBL27789573 | 0.89 | SMN1; SMN2 (0.37) | GPR119SMN1; SMN2KMT2AAOC3SLC6A3 | |
| SCHEMBL27873794 | 0.88 | GPR119 (0.42) | GPR119SMN1; SMN2AOC3SLC6A3DNM1L | |
| SCHEMBL27768028 | 0.88 | GPR119 (0.35) | GPR119SMN1; SMN2KMT2AAOC3DNM1L | |
| SCHEMBL27975186 | 0.82 | KMT2A (0.41) | GPR119SMN1; SMN2KMT2AAOC3SLC6A3 | |
| SCHEMBL907209 | 0.82 | GPR119 (0.58) | GPR119SMN1; SMN2KMT2AF2RL3KDM4E | |
| SCHEMBL27768120 | 0.82 | GPR119 (0.54) | GPR119SMN1; SMN2KMT2ASLC6A3F2RL3 | |
| SCHEMBL27828645 | 0.81 | GPR119 (0.35) | GPR119RAB9AFAAHTMIGD3ADORA1 | |
| SCHEMBL28781307 | 0.80 | GPR119 (0.54) | GPR119SMN1; SMN2KMT2AF2RL3RAB9A | |
| SCHEMBL27789523 | 0.80 | SMN1; SMN2 (0.37) | SMN1; SMN2KMT2AAOC3KDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101616586-B | Heterocyclic receptor agonists for the treatment of diabetes and metabolic disorders | CYMABAY THERAPEUTICS INC | 2014-08-13 | — | — | CN | disclosed |
| CN-102026636-B | Oxymethylene aryl compounds and uses thereof | METABOLEX INC | 2014-07-16 | — | — | CN | disclosed |
| CN-103037843-A | Compositions of 5-ethyl-2- {4- [4- (4-tetrazol-1-yl-phenoxymethyl) -thiazol-2-yl ] -piperidin-1-yl } -pyrimidine | METABOLEX INC | 2013-04-10 | — | — | CN | disclosed |
| CN-102026636-A | Oxymethylene aryl compounds and uses thereof | METABOLEX INC | 2011-04-20 | — | — | CN | disclosed |
| CN-101616586-A | The heterocyclic receptor agonists of treatment diabetes and metabolic disorder | METABOLEX INC | 2009-12-30 | — | — | CN | disclosed |