SCHEMBL27768980

SCHEMBL27768980

O=COc1cccc2cc(O)ccc12

nearest known ligand 0.45

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
CYP1A2 P05177 1/20 0.39
ESR1 P03372 6/20 0.39
ESR2 Q92731 6/20 0.39
TLR8 Q9NR97 1/20 0.39
HSD17B1 P14061 2/20 0.39
HSD17B2 P37059 2/20 0.39
CLK1 P49759 1/20 0.38
DYRK1A Q13627 1/20 0.38
DYRK1B Q9Y463 1/20 0.38
THRA P10827 1/20 0.37
THRB P10828 1/20 0.37
KDM5A P29375 1/20 0.36
NQO2 P16083 1/20 0.36
CCNB2 O95067 1/20 0.36
CDK1 P06493 1/20 0.36
CDK4 P11802 1/20 0.36
CCNB1 P14635 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15946485 0.83 CYP1A2 (0.39) SLC6A2SLC6A4SLC6A3CYP1A2ESR1
SCHEMBL9654195 0.81 CYP1A2 (0.41) SLC6A4CYP1A2
SCHEMBL28118214 0.81 GRIN2D (0.39) CYP1A2ESR1ESR2HSD17B1HSD17B2
SCHEMBL13871447 0.80 CYP1A2 (0.46) SLC6A2SLC6A4SLC6A3CYP1A2ESR1
SCHEMBL28769600 0.79 ERN1 (0.42) SLC6A2SLC6A4CYP1A2POLB
SCHEMBL7037863 0.79 BCHE (0.32)
SCHEMBL7858267 0.79 PLAU (0.49)
SCHEMBL2946 0.77 ALDH1A1 (0.47) SLC6A4
SCHEMBL27301541 0.77 CYP1A2 (0.47) CYP1A2MAOAIDH1
SCHEMBL10745584 0.77 CYP1A2 (0.43) SLC6A2SLC6A4SLC6A3CYP1A2ESR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101468943-B Preparation technique of 1,6-dimethoxynaphthalene NANTONG BAISHENG CHEMICAL INDUSTRY CO LTD 2011-08-31 CN disclosed
CN-101468943-A Preparation technique of 1,6-dimethoxynaphthalene NANTONG LAIJIALI CHEMICAL CO L (CN) 2009-07-01 CN disclosed