Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL391165 | 0.89 | GPR119 (0.71) | GPR119ALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL386088 | 0.86 | GPR119 (0.91) | GPR119CYP2C9KCNH2 | |
| SCHEMBL390792 | 0.83 | GPR119 (0.69) | GPR119NPC1RAB9AKDM4ECYP2C9 | |
| SCHEMBL389883 | 0.81 | GPR119 (1.00) | GPR119CYP2C9KCNH2 | |
| SCHEMBL12835887 | 0.81 | GPR119 (0.79) | GPR119ALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL390865 | 0.81 | GPR119 (0.95) | GPR119CYP2C9KCNH2 | |
| SCHEMBL389690 | 0.80 | GPR119 (1.00) | GPR119ALDH1A1HSD17B10HPGDNPC1 | |
| SCHEMBL391174 | 0.78 | GPR119 (0.64) | GPR119ALDH1A1SMN1; SMN2CYP2C9KCNH2 | |
| SCHEMBL13685456 | 0.78 | GPR119 (0.51) | GPR119ALDH1A1HSD17B10HPGDSMN1; SMN2 | |
| SCHEMBL389635 | 0.78 | GPR119 (0.83) | GPR119CYP2C9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101420941-A | Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, and related combination therapies | ARENA PHARM INC (US) | 2009-04-29 | — | — | CN | disclosed |