SCHEMBL27769059

SCHEMBL27769059

CC(C)CNc1ccc(Nc2cc(OC3CCN(C(=O)OC(C)C)CC3)ncn2)cn1

nearest known ligand 0.57

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 20/20 0.57
CYP2C9 P11712 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28781405 0.87 GPR119 (0.57) GPR119CYP2C9
SCHEMBL391312 0.87 GPR119 (0.59) GPR119CYP2C9
SCHEMBL389671 0.86 GPR119 (0.60) GPR119CYP2C9
SCHEMBL386567 0.82 GPR119 (0.60) GPR119CYP2C9
SCHEMBL390248 0.82 GPR119 (0.64) GPR119CYP2C9
SCHEMBL390044 0.82 GPR119 (0.63) GPR119CYP2C9
SCHEMBL387108 0.82 GPR119 (0.55) GPR119
SCHEMBL391164 0.81 GPR119 (0.60) GPR119CYP2C9
SCHEMBL386797 0.81 GPR119 (0.77) GPR119CYP2C9
SCHEMBL391546 0.80 GPR119 (0.59) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101420941-A Use of GPR119 receptor agonists for increasing bone mass and for treating osteoporosis, and related combination therapies ARENA PHARM INC (US) 2009-04-29 CN disclosed