Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 7/20 | 0.44 |
| ▸ | SOAT1 | P35610 | 3/20 | 0.36 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | FAAH | O00519 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.35 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.35 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.35 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.35 |
| ▸ | GABRA3 | P34903 | 3/20 | 0.35 |
| ▸ | GABRA2 | P47869 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4472648 | 0.88 | DGAT1 (0.43) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL14813144 | 0.88 | DGAT1 (0.43) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL27769398 | 0.84 | CCNE1 (0.39) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL27769433 | 0.84 | SYK (0.38) | GABRA1GABRG2GABRB3GABRA5GABRA3 | |
| SCHEMBL27790808 | 0.79 | DGAT1 (0.43) | DGAT1SOAT1JAK2JAK1TYK2 | |
| SCHEMBL14813112 | 0.78 | DGAT1 (0.50) | DGAT1SOAT1JAK2JAK1TYK2 | |
| SCHEMBL4472216 | 0.78 | DGAT1 (0.50) | DGAT1SOAT1JAK2JAK1TYK2 | |
| SCHEMBL4487832 | 0.77 | DGAT1 (0.45) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL4943216 | 0.76 | DGAT1 (0.44) | DGAT1SOAT1FAAHCHRM2DGAT2 | |
| SCHEMBL4482968 | 0.73 | DGAT1 (0.44) | DGAT1SOAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101636155-A | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LAB | 2010-01-27 | — | — | CN | claimed |
| CN-101636155-A | Inhibitors of diacylglycerol O-acyltransferase type 1 enzyme | ABBOTT LAB | 2010-01-27 | — | — | CN | disclosed |