Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PPARD | Q03181 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4862481 | 0.84 | PDE2A (0.43) | PDE2ANPC1ALDH1A1GAAPPARD | |
| SCHEMBL3375383 | 0.84 | PDE2A (0.43) | PDE2ANPC1ALDH1A1GAAPPARD | |
| SCHEMBL4862477 | 0.84 | PDE2A (0.43) | PDE2ANPC1ALDH1A1GAAPPARD | |
| SCHEMBL23367934 | 0.84 | PDE2A (0.44) | PDE2ANPC1ALDH1A1GAAPPARD | |
| SCHEMBL4860740 | 0.81 | PDE2A (0.43) | PDE2ANPC1ALDH1A1GAAPPARD | |
| SCHEMBL27650502 | 0.81 | PDE2A (0.43) | PDE2ANPC1ALDH1A1GAAPPARD | |
| SCHEMBL4860735 | 0.81 | PDE2A (0.43) | PDE2ANPC1ALDH1A1GAAPPARD | |
| SCHEMBL27499643 | 0.81 | SMN1; SMN2 (0.50) | NPC1ALDH1A1MAPTKDM4EMEN1 | |
| SCHEMBL27769542 | 0.81 | PDE2A (0.43) | PDE2ANPC1ALDH1A1GAAPPARD | |
| SCHEMBL27856860 | 0.77 | SMN1; SMN2 (0.42) | ALDH1A1KDM4ERAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101479008-B | PPAR-delta agonist benzazepine-oxyacetic acid derivatives for raising HDL-C, lowering LDL-C and lowering cholesterol | JANSSEN PHARMACEUTICA NV | 2013-07-17 | — | — | CN | disclosed |
| CN-101479008-A | Benza -oxyacetic acid derivatives as PPAR-delta agonists for raising HDL-C, lowering LDL-C and lowering cholesterol | JANSSEN PHARMACEUTICA NV (BE) | 2009-07-08 | — | — | CN | disclosed |