Known targets — ChEMBL curated mechanism
ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Dimethylformamide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA4 | P22748 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylformamide SCHEMBL2022284 | 0.94 | TSHR (0.56) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL6666132 | 0.94 | CA1 (0.56) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL28095581 | 0.94 | TSHR (0.56) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL10800682 | 0.94 | TSHR (0.56) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL11454512 | 0.94 | TSHR (0.56) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL20398853 | 0.90 | TSHR (0.60) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL9574669 | 0.84 | TSHR (0.60) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL5002230 | 0.84 | TSHR (0.60) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL7257761 | 0.84 | TSHR (0.60) | TSHRCA1CA4 | |
| Dimethylformamide SCHEMBL1634019 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102942603-B | New aminoglycoside antibiotics | MEIJI SEIKA PHARMA CO., LTD. (JP) | 2016-01-20 | — | — | CN | disclosed |
| CN-101495493-B | Novel aminoglycoside antibiotics | MEIJI SEIKA KAISHA (JP) | 2012-11-14 | — | — | CN | disclosed |
| CN-101495493-A | Novel aminoglycoside antibiotics | MEIJI SEIKA KAISHA (JP) | 2009-07-29 | — | — | CN | disclosed |