Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13254660 | 1.00 | HMGCR (0.31) | HMGCRCHRM1TBXA2RADRA1A | |
| SCHEMBL11941366 | 0.80 | — | — | |
| SCHEMBL14616966 | 0.77 | — | — | |
| SCHEMBL9004541 | 0.75 | — | — | |
| SCHEMBL1487695 | 0.74 | NFE2L2 (0.35) | — | |
| SCHEMBL1487696 | 0.74 | NFE2L2 (0.35) | — | |
| SCHEMBL10750279 | 0.73 | TDP1 (0.45) | — | |
| SCHEMBL10750284 | 0.73 | TDP1 (0.45) | — | |
| SCHEMBL21764601 | 0.73 | GABRR1 (0.46) | — | |
| SCHEMBL10586612 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101835771-A | Aminobenzyl-substituted cyclic sulfones useful as bace inhibitors | NOVARTIS AG | 2010-09-15 | — | — | CN | disclosed |
| CN-101490018-A | Macrocyclic compounds useful as BACE inhibitors | NOVARTIS AG (CH) | 2009-07-22 | — | — | CN | disclosed |