Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | CA9 | Q16790 | 2/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 5/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 5/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 5/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 5/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2777261 | 0.97 | HSD17B10 (0.45) | HSD17B10CA1CA2CA9CA14 | |
| SCHEMBL2777587 | 0.93 | NOTUM (0.44) | HSD17B10NOTUMKDRBRAFMAPK14 | |
| SCHEMBL2779000 | 0.84 | HSD17B10 (0.43) | HSD17B10CA1CA2CA9CA14 | |
| SCHEMBL2780386 | 0.84 | KDR (0.49) | HSD17B10KDM4EKDRBRAFMAPK14 | |
| SCHEMBL2776079 | 0.81 | HSD17B10 (0.47) | HSD17B10CA1CA2CA9CA14 | |
| SCHEMBL2778534 | 0.81 | KDR (0.48) | HSD17B10KDRBRAFMAPK14TNNI3K | |
| SCHEMBL2779088 | 0.81 | NOTUM (0.45) | HSD17B10NOTUMCHRM1UCHL1OPRM1 | |
| SCHEMBL14351966 | 0.79 | LOXL2 (0.47) | HSD17B10NOTUMMAPTUCHL1OPRM1 | |
| SCHEMBL2706559 | 0.79 | KDR (0.46) | KDR | |
| SCHEMBL12972237 | 0.79 | KDR (0.62) | KDRBRAFMAPK14TNNI3KMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7855215-B2 | Cyclic diaryl ureas suitable as tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2010-12-21 | — | — | US | disclosed |
| US-20080039440-A1 | Cyclic Diaryl Ureas Suitable as Tyrosine Kinase Inhibitors | BOLD GUIDO | 2008-02-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080039440-A1 | Cyclic Diaryl Ureas Suitable as Tyrosine Kinase Inhibitors | RET, ROS1, BRAF | HSD17B10 2798/4885CA1 1364/4885CA2 1276/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.