Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 1/20 | 0.41 |
| ▸ | CHKA | P35790 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HBB | P68871 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | RAF1 | P04049 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13338165 | 0.84 | CHRM5 (0.45) | CHRM5CHKAMAPTSMN1; SMN2SLC6A2 | |
| SCHEMBL5998653 | 0.75 | CHRM5 (0.52) | CHRM5CHKAMAPTSMN1; SMN2SLC6A2 | |
| SCHEMBL5998627 | 0.75 | CHRM5 (0.52) | CHRM5CHKAMAPTSMN1; SMN2SLC6A2 | |
| SCHEMBL1076934 | 0.75 | ALDH1A1 (0.43) | MEN1NPC1ALOX15RAB9AKMT2A | |
| SCHEMBL3409151 | 0.74 | CHRM5 (0.68) | CHRM5CHKAMAPTSMN1; SMN2SLC6A2 | |
| SCHEMBL5998795 | 0.71 | GRM5 (0.45) | CHRM5CHKASLC6A2NPC1RAB9A | |
| SCHEMBL6000218 | 0.71 | ABCG2 (0.46) | CHRM5CHKASLC6A2NPC1RAB9A | |
| SCHEMBL2222390 | 0.71 | CHKA (0.52) | CHRM5CHKAMAPTSMN1; SMN2MEN1 | |
| SCHEMBL13338174 | 0.69 | CHKA (0.45) | CHRM5CHKAMAPTSMN1; SMN2SLC6A2 | |
| SCHEMBL13338166 | 0.69 | CHRM5 (0.45) | CHRM5CHKAMAPTSMN1; SMN2SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101501041-A | Amino-imidazolones and their use as medicaments for the treatment of cognitive impairment, Alzheimer's disease, neurodegeneration and dementia | ASTRAZENECA AB (SE) | 2009-08-05 | — | — | CN | disclosed |