Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 4/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.42 |
| ▸ | MTOR | P42345 | 5/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.39 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | TGFB2 | P61812 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27775553 | 0.83 | TGFB2 (0.41) | PIK3CAMTORKDM4EPIK3CGTGFB2 | |
| SCHEMBL27775538 | 0.80 | PIK3CD (0.45) | CYP1A2CYP2C9FGFR3KDRPIK3CA | |
| SCHEMBL2545603 | 0.79 | CKS1B (0.52) | CYP1A2PIK3CAPIK3CDMTORCYP3A4 | |
| SCHEMBL3631469 | 0.77 | PIK3CA (0.42) | CYP1A2FGFR3KDRPIK3CAPIK3CD | |
| Tert-Butyl Formate SCHEMBL27634126 | 0.77 | ADRB1 (0.47) | CYP1A2CYP2C9CYP3A4CYP2C19TGFB2 | |
| Tert-Butyl Formate SCHEMBL28809624 | 0.76 | HRH3 (0.43) | HRH4HRH3 | |
| SCHEMBL27700088 | 0.75 | PIK3CA (0.72) | PIK3CAPIK3CDMTORPIK3CGATR | |
| Tert-Butyl Formate SCHEMBL29286245 | 0.73 | PIK3CA (0.39) | PIK3CAMTORMEN1KMT2APIK3CG | |
| SCHEMBL5593037 | 0.72 | PIK3CA (0.66) | PIK3CAPIK3CDMTORHSD17B10PIK3CG | |
| Tert-Butyl Formate SCHEMBL28866007 | 0.72 | HRH4 (0.58) | CYP1A2CYP2C9HRH4HSD17B10HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679401-B | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as MET kinase inhibitors for the treatment of tumors | MERCK PATENT GMBH | 2012-12-12 | — | — | CN | disclosed |
| CN-101679401-A | 2-oxo-3-benzyl-benzoxazol-2-one derivatives and related compounds as MET kinase inhibitors for the treatment of tumors | MERCK PATENT GMBH | 2010-03-24 | — | — | CN | disclosed |