Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 5/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | BRCA1 | P38398 | 2/20 | 0.55 |
| ▸ | USP2 | O75604 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 3/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27796463 | 0.92 | CSNK2A1 (0.61) | CSNK2A1HSD17B10KDM4EBRCA1USP2 | |
| SCHEMBL27775418 | 0.89 | CSNK2A1 (0.58) | CSNK2A1HSD17B10KDM4EBRCA1USP2 | |
| SCHEMBL27775980 | 0.86 | CSNK2A1 (0.61) | CSNK2A1HSD17B10KDM4EBRCA1USP2 | |
| SCHEMBL300795 | 0.85 | KDM4E (0.59) | CSNK2A1HSD17B10KDM4EBRCA1USP2 | |
| SCHEMBL27775317 | 0.83 | CSNK2A1 (0.81) | CSNK2A1HSD17B10KDM4EBRCA1USP2 | |
| SCHEMBL27775404 | 0.82 | CSNK2A1 (0.59) | CSNK2A1HSD17B10KDM4EBRCA1USP2 | |
| SCHEMBL27775389 | 0.82 | CSNK2A1 (0.62) | CSNK2A1HSD17B10KDM4EBRCA1USP2 | |
| SCHEMBL27796506 | 0.81 | CSNK2A1 (0.53) | CSNK2A1HSD17B10KDM4EBRCA1USP2 | |
| SCHEMBL27796442 | 0.80 | CSNK2A1 (0.84) | CSNK2A1HSD17B10KDM4EBRCA1USP2 | |
| SCHEMBL27775430 | 0.78 | XDH (0.50) | CSNK2A1USP2MAPK1TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679432-B | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | SIGNAL PHARM LLC | 2015-04-22 | — | — | CN | claimed |
| CN-105039520-A | Identification of gene expression profile as a predictive biomarker for lkb1 status | SIGNAL PHARM LLC | 2015-11-11 | — | — | CN | disclosed |
| CN-101679432-B | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | SIGNAL PHARM LLC | 2015-04-22 | — | — | CN | disclosed |
| CN-103857804-A | Identification of gene expression profiles as predictive biomarkers for LKB1 status | SIGNAL PHARM LLC | 2014-06-11 | — | — | CN | disclosed |
| CN-101679432-A | Heteroaryl compounds, compositions thereof, and their use as protein kinase inhibitors | SIGNAL PHARM LLC | 2010-03-24 | — | — | CN | disclosed |