Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCK | P35557 | 4/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 3/20 | 0.39 |
| ▸ | FSCN1 | Q16658 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 4/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 3/20 | 0.35 |
| ▸ | CACNA1I | Q9P0X4 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27776167 | 0.93 | GCK (0.42) | GCKP2RX7PTGDR2CACNA1HCACNA1G | |
| SCHEMBL27797061 | 0.90 | GCK (0.42) | GCKP2RX7PTGDR2CACNA1HCACNA1G | |
| SCHEMBL2662206 | 0.89 | GCK (0.42) | GCKP2RX7PTGDR2FSCN1GRM4 | |
| SCHEMBL27796881 | 0.87 | P2RX7 (0.39) | P2RX7FSCN1GRM4PPARG | |
| SCHEMBL2662044 | 0.87 | GCK (0.41) | GCKPTGDR2FSCN1GRM4CACNA1H | |
| SCHEMBL3748346 | 0.86 | GCK (0.41) | GCKP2RX7PTGDR2FSCN1CACNA1H | |
| SCHEMBL27776182 | 0.86 | GCK (0.42) | GCKPTGDR2GRM4SMN1; SMN2 | |
| SCHEMBL2659660 | 0.85 | GCK (0.37) | GCKPTGDR2FSCN1PPARG | |
| SCHEMBL3741556 | 0.84 | GCK (0.45) | GCKPTGDR2FSCN1CACNA1H | |
| SCHEMBL2661611 | 0.84 | GCK (0.39) | GCKPTGDR2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101679365-A | As the new pyrrole-2-carboxamides derivatives of glucokinase activators, their manufacture method and pharmaceutical application | ADVINUS THERAPEUTICS PRIVATE L | 2010-03-24 | — | — | CN | claimed |
| CN-101679365-A | As the new pyrrole-2-carboxamides derivatives of glucokinase activators, their manufacture method and pharmaceutical application | ADVINUS THERAPEUTICS PRIVATE L | 2010-03-24 | — | — | CN | disclosed |