Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | GLA | P06280 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.45 |
| ▸ | CA6 | P23280 | 3/20 | 0.45 |
| ▸ | CA7 | P43166 | 3/20 | 0.45 |
| ▸ | CA9 | Q16790 | 3/20 | 0.45 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.45 |
| ▸ | CA5B | Q9Y2D0 | 3/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.43 |
| ▸ | CA3 | P07451 | 2/20 | 0.43 |
| ▸ | CA4 | P22748 | 2/20 | 0.43 |
| ▸ | CA5A | P35218 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL28471875 | 0.97 | CYP2C19 (0.43) | CYP2C19MEN1KMT2AGLACA12 | |
| Piperazine SCHEMBL28008800 | 0.95 | CA12 (0.52) | CYP2C19MEN1KMT2AGLACA12 | |
| Piperazine SCHEMBL27503247 | 0.95 | CA12 (0.52) | CYP2C19MEN1KMT2AGLACA12 | |
| Piperazine SCHEMBL11591607 | 0.86 | CA12 (0.62) | CYP2C19MEN1KMT2ACA12CA6 | |
| SCHEMBL199119 | 0.86 | — | — | |
| SCHEMBL8624359 | 0.86 | CA12 (0.60) | CYP2C19MEN1KMT2AGLACA12 | |
| Piperazine SCHEMBL9063706 | 0.83 | CA12 (0.65) | CYP2C19MEN1KMT2ACA12CA6 | |
| SCHEMBL11427378 | 0.83 | CA12 (0.67) | CYP2C19MEN1KMT2AGLACA12 | |
| SCHEMBL10874057 | 0.83 | CA12 (0.62) | CYP2C19MEN1KMT2AGLACA12 | |
| Ammonia Solution, Strong SCHEMBL3069751 | 0.83 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112867748-B | Ultra-fast cyclic ether-amine photopolymerization and use thereof | 上阿尔萨斯大学 | 2024-03-08 | — | — | CN | claimed |
| CN-116867810-A | Rubber vulcanization method using eutectic mixture | 株式会社普利司通 | 2023-10-10 | — | — | CN | claimed |
| CN-113874434-B | Rubber composition for pneumatic tire | 株式会社普利司通 | 2024-03-01 | — | — | CN | disclosed |
| CN-116867810-A | Rubber vulcanization method using eutectic mixture | 株式会社普利司通 | 2023-10-10 | — | — | CN | disclosed |
| CN-110831922-B | Method for producing chain-extended hydroxyethylethyleneamines, ethyleneamines or mixtures thereof | 诺力昂化学品国际有限公司 | 2022-12-23 | — | — | CN | disclosed |
| CN-110072841-B | Method for producing hydroxyethylethylene amines | 阿克苏诺贝尔化学品国际有限公司 | 2022-04-19 | — | — | CN | disclosed |
| CN-110072838-B | Process for preparing ethyleneamines | 阿克苏诺贝尔化学品国际有限公司 | 2022-04-15 | — | — | CN | disclosed |
| CN-110997638-A | Process for preparing cyclic urea adducts of ethylene amine compounds | 诺力昂化学品国际有限公司 | 2020-04-10 | — | — | CN | disclosed |
| CN-110831922-A | Method for producing chain-extended hydroxyethylethyleneamines, ethyleneamines or mixtures thereof | 诺力昂化学品国际有限公司 | 2020-02-21 | — | — | CN | disclosed |
| CN-110072841-A | The method for preparing ethoxy ethylene amines | 阿克苏诺贝尔化学品国际有限公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-110072838-A | Process for preparing ethyleneamines | 阿克苏诺贝尔化学品国际有限公司 | 2019-07-30 | — | — | CN | disclosed |
| CN-104981257-A | Method for producing water-absorbing polymer particles | BASF SE | 2015-10-14 | — | — | CN | disclosed |
| CN-101675025-B | Method for producing tetraethylenepentamine | BASF SE | 2015-04-08 | — | — | CN | disclosed |
| CN-104427867-A | Highly concentrated aqueous formulation comprising anionic pesticide and a base | BASF SE | 2015-03-18 | — | — | CN | disclosed |
| CN-104411172-A | Drift prevention agent comprising polypropylene glycol and triblock polymer | BASF SE | 2015-03-11 | — | — | CN | disclosed |
| CN-104394692-A | An aqueous composition comprising dicamba and a drift control agent | BASF SE | 2015-03-04 | — | — | CN | disclosed |
| CN-101675025-A | Method for producing tetraethylenepentamine | BASF SE | 2010-03-17 | — | — | CN | disclosed |