Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 known ✓ | P03372 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 5/20 | 0.62 |
| ▸ | CA6 | P23280 | 5/20 | 0.62 |
| ▸ | CA7 | P43166 | 5/20 | 0.62 |
| ▸ | CA9 | Q16790 | 5/20 | 0.62 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.62 |
| ▸ | CA5B | Q9Y2D0 | 5/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.62 |
| ▸ | RECQL | P46063 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | CA2 | P00918 | 4/20 | 0.59 |
| ▸ | CA4 | P22748 | 4/20 | 0.59 |
| ▸ | CA5A | P35218 | 4/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | CA3 | P07451 | 3/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL9063706 | 0.97 | CA12 (0.65) | CA12CA6CA7CA9CA14 | |
| SCHEMBL15569825 | 0.92 | CA12 (0.53) | CA12CA6CA7CA9CA14 | |
| Piperazine SCHEMBL27503247 | 0.87 | CA12 (0.52) | CA12CA6CA7CA9CA14 | |
| Piperazine SCHEMBL28008800 | 0.87 | CA12 (0.52) | CA12CA6CA7CA9CA14 | |
| Piperazine SCHEMBL27776384 | 0.86 | CYP2C19 (0.46) | CA12CA6CA7CA9CA14 | |
| Piperidine SCHEMBL5669654 | 0.86 | CA12 (0.53) | CA12CA6CA7CA9CA14 | |
| Piperazine SCHEMBL28471875 | 0.84 | CYP2C19 (0.43) | CA12CA6CA7CA9CA14 | |
| Spermine SCHEMBL5375346 | 0.82 | CA12 (0.72) | CA12CA6CA7CA9CA14 | |
| SCHEMBL15381 | 0.79 | — | — | |
| SCHEMBL5314937 | 0.79 | CA12 (1.00) | CA12CA6CA7CA9CA14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4089840-A | Process for the production of epoxy silicate resinous products | BLOUNT DAVID H | 1978-05-16 | — | — | US | claimed |