Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 12/20 | 0.63 |
| ▸ | NTRK1 | P04629 | 4/20 | 0.44 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL306808 | 1.00 | P2RX7 (0.63) | P2RX7NTRK1NLRP3CNR2LMNA | |
| SCHEMBL308141 | 0.90 | P2RX7 (0.76) | P2RX7NTRK1NLRP3LMNAPOLB | |
| SCHEMBL14407705 | 0.90 | P2RX7 (0.76) | P2RX7NTRK1NLRP3LMNAPOLB | |
| SCHEMBL306906 | 0.89 | P2RX7 (0.66) | P2RX7NTRK1LMNA | |
| SCHEMBL27776446 | 0.89 | P2RX7 (0.66) | P2RX7NTRK1LMNA | |
| SCHEMBL305748 | 0.88 | P2RX7 (0.58) | P2RX7NTRK1NLRP3CNR2LMNA | |
| SCHEMBL306152 | 0.88 | P2RX7 (0.58) | P2RX7NTRK1NLRP3CNR2LMNA | |
| SCHEMBL305747 | 0.88 | P2RX7 (0.58) | P2RX7NTRK1NLRP3CNR2LMNA | |
| SCHEMBL308147 | 0.87 | P2RX7 (0.59) | P2RX7NTRK1NLRP3POLBKCNJ5 | |
| SCHEMBL27776464 | 0.87 | P2RX7 (0.59) | P2RX7NTRK1NLRP3POLBKCNJ5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101686680-A | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC | 2010-03-31 | — | — | CN | claimed |
| CN-101686680-A | Bicyclic heteroaryl compounds as P2X7 modulators and uses thereof | RENOVIS INC | 2010-03-31 | — | — | CN | disclosed |