Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE7A | Q13946 | 7/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.54 |
| ▸ | PDE10A | Q9Y233 | 7/20 | 0.54 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | PLAUR | Q03405 | 3/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | CASP7 | P55210 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2780557 | 0.83 | KCNK3 (0.55) | PDE7APDE3APDE10AKCNK3GAA | |
| SCHEMBL12963808 | 0.81 | PDE10A (0.72) | PDE7APDE3APDE10AKCNK3NPC1 | |
| SCHEMBL2775500 | 0.81 | KCNK3 (0.48) | PDE7APDE3APDE10AKCNK3SMN1; SMN2 | |
| SCHEMBL2777693 | 0.79 | KCNK3 (0.43) | PDE7APDE3APDE10AKCNK3GAA | |
| SCHEMBL12972204 | 0.78 | PDE10A (0.51) | PDE7APDE3APDE10AKCNK3GAA | |
| SCHEMBL31105163 | 0.78 | KCNK3 (0.50) | PDE7APDE3APDE10AKCNK3GAA | |
| SCHEMBL2774365 | 0.78 | KCNK3 (0.43) | PDE7APDE3APDE10AKCNK3RAB9A | |
| SCHEMBL31105219 | 0.77 | KCNK3 (0.49) | PDE7APDE3APDE10AKCNK3RAB9A | |
| SCHEMBL2777603 | 0.77 | CNR1 (0.54) | PDE7APDE3APDE10ARAB9AMAPT | |
| SCHEMBL2776695 | 0.77 | KCNK3 (0.43) | PDE7APDE3APDE10AKCNK3GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2435433-B1 | (DIHYDRO)IMIDAZOISO[5,1-A]QUINOLINES AS FSH RECEPTOR AGONISTS FOR THE TREATMENT OF FERTILITY DISORDERS | MERCK SHARP & DOHME (NL) | 2013-08-28 | — | — | EP | disclosed |
| US-8071587-B2 | (Dihydro)imidazoiso[5,1-A]quinolines | N. V. ORGANON (NL) | 2011-12-06 | — | — | US | disclosed |
| US-20100324021-A1 | (DIHYDRO)IMIDAZOISO[5,1-A]QUINOLINES | N.V. ORGANON (NL) | 2010-12-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324021-A1 | (DIHYDRO)IMIDAZOISO[5,1-A]QUINOLINES | NQO2, IPO5, SCN5A | PDE7A 417/4885PDE3A 170/4885PDE10A 919/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.