Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 10/20 | 0.42 |
| ▸ | FLT1 | P17948 | 5/20 | 0.42 |
| ▸ | TEK | Q02763 | 4/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.40 |
| ▸ | SRC | P12931 | 2/20 | 0.40 |
| ▸ | FLT4 | P35916 | 2/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CDK2 | P24941 | 1/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.40 |
| ▸ | GSK3B | P49841 | 1/20 | 0.40 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 4/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | LYN | P07948 | 1/20 | 0.39 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3619641 | 0.94 | RIPK1 (0.45) | RIPK1FLT1TEKCSF1RSRC | |
| SCHEMBL27780722 | 0.88 | TEK (0.56) | RIPK1FLT1TEKCSF1RSRC | |
| SCHEMBL3620600 | 0.87 | RIPK1 (0.44) | RIPK1FLT1TEKCSF1RSRC | |
| SCHEMBL3621408 | 0.86 | FLT1 (0.40) | RIPK1FLT1TEKCSF1RSRC | |
| SCHEMBL27682717 | 0.85 | BTK (0.42) | RIPK1FLT1TEKCSF1RSRC | |
| SCHEMBL15221994 | 0.83 | KDR (0.42) | RIPK1FLT1TEKCSF1RSRC | |
| SCHEMBL275476 | 0.82 | RIPK1 (0.45) | RIPK1FLT1TEKCSF1RSRC | |
| SCHEMBL275201 | 0.82 | RIPK1 (0.44) | RIPK1FLT1TEKCSF1RSRC | |
| SCHEMBL3619710 | 0.82 | TEK (0.57) | RIPK1FLT1TEKCSF1RSRC | |
| SCHEMBL275915 | 0.82 | BTK (0.46) | RIPK1FLT1TEKCSF1RSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1993361-B | Pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER PHARMACEUTICALS CORP | 2010-05-26 | — | — | CN | disclosed |