Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 7/20 | 0.41 |
| ▸ | SMARCA4 | P51532 | 6/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.37 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 1/20 | 0.36 |
| ▸ | CDK8 | P49336 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | LOX | P28300 | 1/20 | 0.36 |
| ▸ | LOXL3 | P58215 | 1/20 | 0.36 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.36 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.36 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.36 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.35 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2183698 | 0.87 | AKR1C3 (0.44) | RECQLAKR1C3AKR1C2 | |
| SCHEMBL29272210 | 0.83 | PTGS1 (0.47) | SMARCA2SMARCA4FFAR2OPRM1OPRK1 | |
| SCHEMBL13332664 | 0.80 | GPR119 (0.44) | SMARCA2SMARCA4RECQLAKR1C3AKR1C2 | |
| SCHEMBL1979197 | 0.80 | GPR119 (0.44) | SMARCA2SMARCA4RECQLAKR1C3AKR1C2 | |
| SCHEMBL27924260 | 0.79 | PSEN1 (0.44) | SMARCA2SMARCA4 | |
| SCHEMBL2040052 | 0.79 | RECQL (0.44) | SMARCA2SMARCA4RECQLFFAR2OPRM1 | |
| SCHEMBL30003916 | 0.79 | RECQL (0.44) | SMARCA2SMARCA4RECQLFFAR2OPRM1 | |
| SCHEMBL4330263 | 0.79 | RECQL (0.44) | SMARCA2SMARCA4RECQLFFAR2OPRM1 | |
| SCHEMBL2759112 | 0.78 | RECQL (0.42) | SMARCA2SMARCA4RECQLFFAR2OPRM1 | |
| SCHEMBL27845906 | 0.78 | KDM1A (0.37) | RIOK2AKR1C3AKR1C2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101627007-A | Aminoamides as orexin antagonists | HOFFMANN LA ROCHE | 2010-01-13 | — | — | CN | disclosed |
| CN-101516874-A | Pyrrole derivatives for the treatment of cytokine mediated diseases | NOVARTIS AG (CH) | 2009-08-26 | — | — | CN | disclosed |