Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 5/20 | 0.41 |
| ▸ | PAK1 | Q13153 | 7/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 3/20 | 0.39 |
| ▸ | SGK1 | O00141 | 3/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.39 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | MAP3K11 | Q16584 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27782909 | 0.91 | AAK1 (0.44) | AAK1AXLPAK1BRD4PKN1 | |
| SCHEMBL27804369 | 0.86 | AAK1 (0.42) | AAK1AXLPAK1CAMKK2SGK1 | |
| SCHEMBL858775 | 0.85 | MAP3K11 (0.49) | AAK1AXLPAK1CAMKK2SGK1 | |
| SCHEMBL14620851 | 0.83 | AXL (0.60) | AAK1AXLPAK1CAMKK2SGK1 | |
| SCHEMBL1362857 | 0.78 | AXL (0.62) | AAK1AXLPAK1BRD4PKN1 | |
| SCHEMBL857104 | 0.78 | AXL (0.56) | AAK1AXLPAK1CAMKK2BRD4 | |
| SCHEMBL858644 | 0.78 | BRD4 (0.51) | AAK1AXLPAK1BRD4 | |
| SCHEMBL27782820 | 0.77 | AAK1 (0.44) | AAK1AXLPAK1CAMKK2BRD4 | |
| SCHEMBL859097 | 0.77 | KIT (0.52) | AAK1AXLPAK1PKN1 | |
| SCHEMBL27804440 | 0.76 | AAK1 (0.43) | AAK1AXLPAK1CAMKK2SGK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1925855-B | Compounds and methods for development of Ret modulators | PLEXXIKON INC | 2010-06-16 | — | — | CN | claimed |