Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3042184 | 0.83 | SCD (0.60) | HPGDRAB9APOLBTSHRALDH1A1 | |
| SCHEMBL12195636 | 0.78 | TSHR (0.62) | HPGDRAB9APOLBTSHRALDH1A1 | |
| SCHEMBL3046884 | 0.77 | TSHR (0.51) | HPGDPOLBTSHRALDH1A1USP2 | |
| SCHEMBL3051517 | 0.76 | HPGD (0.57) | HPGDRAB9APOLBTSHRALDH1A1 | |
| SCHEMBL3456455 | 0.73 | LMNA (0.47) | HPGDRAB9APOLBTSHRALDH1A1 | |
| SCHEMBL3043695 | 0.73 | HPGD (0.54) | HPGDRAB9APOLBTSHRALDH1A1 | |
| SCHEMBL3045362 | 0.73 | SCD (0.70) | RAB9APOLBCHRM4SCD | |
| SCHEMBL14162241 | 0.71 | SCD (0.45) | HPGDRAB9APOLBTSHRALDH1A1 | |
| SCHEMBL15421497 | 0.70 | NAMPT (0.62) | HPGDRAB9ATSHRALDH1A1USP2 | |
| SCHEMBL11535238 | 0.69 | TSHR (0.56) | HPGDTSHRALDH1A1USP2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101595105-B | 2-substituted 5-membered heterocycles as SCD inhibitors | NOVARTIS AG | 2013-01-23 | — | — | CN | disclosed |
| CN-101595105-A | 5 membered heterocyclic compounds that replace as the 2-of SCD inhibitor | NOVARTIS AG XENON PHARMACEUTIC (CH) | 2009-12-02 | — | — | CN | disclosed |