Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHUK | O15111 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 1/20 | 0.41 |
| ▸ | PARP1 | P09874 | 2/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 13/20 | 0.39 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27767460 | 0.90 | CDC7 (0.44) | BRD4CDC7CSF1RCCNA2CDK2 | |
| SCHEMBL27789089 | 0.89 | CDC7 (0.45) | IKBKBBRD4CDC7CCNA2CDK2 | |
| SCHEMBL27767430 | 0.86 | PARP1 (0.46) | CHUKIKBKBPARP1BRD4CDC7 | |
| SCHEMBL27788861 | 0.85 | BRD4 (0.41) | PARP1BRD4CDC7CCNA2CDK2 | |
| SCHEMBL27767423 | 0.84 | CDC7 (0.52) | BRD4CDC7CCNA2CDK2CCNA1 | |
| SCHEMBL27767416 | 0.84 | CDC7 (0.52) | IKBKBBRD4CDC7CCNA2CDK2 | |
| SCHEMBL27788862 | 0.84 | BRD4 (0.56) | IKBKBBRD4CDC7CCNA2CDK2 | |
| SCHEMBL27788978 | 0.82 | BRD4 (0.39) | PARP1BRD4CDC7CCNA2CDK2 | |
| SCHEMBL27767429 | 0.82 | CDC7 (0.45) | PARP1BRD4CDC7CCNA2CDK2 | |
| SCHEMBL27767432 | 0.81 | PARP10 (0.43) | BRD4CDC7MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101622229-B | Pyrrole derivatives having ureido and aminocarbonyl groups as substituents | SANTEN PHARMACEUTICAL CO LTD | 2013-02-27 | — | — | CN | disclosed |
| CN-101622229-A | Novel pyrrole derivatives having ureido group and aminocarbonyl group as substituents | SANTEN PHARMACEUTICAL CO LTD | 2010-01-06 | — | — | CN | disclosed |