Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 3/20 | 0.56 |
| ▸ | NOS1 | P29475 | 3/20 | 0.56 |
| ▸ | NOS2 | P35228 | 3/20 | 0.56 |
| ▸ | SLC7A5 | Q01650 | 8/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.56 |
| ▸ | ALPI | P09923 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | XIAP | P98170 | 1/20 | 0.56 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.54 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.49 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | FYN | P06241 | 1/20 | 0.49 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2778977 | 1.00 | NOS3 (0.56) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| Hydrochloric Acid SCHEMBL6775848 | 0.99 | NOS3 (0.55) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| Hydrochloric Acid SCHEMBL6775851 | 0.99 | NOS3 (0.55) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| Hydrochloric Acid SCHEMBL6775846 | 0.99 | NOS3 (0.55) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL2778005 | 0.85 | SLC7A5 (0.59) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| SCHEMBL2478655 | 0.85 | SLC7A5 (0.59) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| Hydrochloric Acid SCHEMBL6774618 | 0.84 | SLC7A5 (0.57) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| Hydrochloric Acid SCHEMBL6771064 | 0.84 | SLC7A5 (0.57) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| Hydrochloric Acid SCHEMBL6771068 | 0.84 | SLC7A5 (0.57) | NOS3NOS1NOS2SLC7A5PTGS1 | |
| Metamelfalan SCHEMBL2015272 | 0.83 | CYP3A4 (0.70) | NOS3NOS1NOS2SLC7A5PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2248901-A1 | Streptogramines and method for preparing same by mutasynthesis | Aventis Pharma S.A. (FR) | 2010-11-10 | — | — | EP | disclosed |
| EP-0770132-B1 | NEW STREPTOGRAMINES | AVENTIS PHARMA SA (FR) | 2010-09-08 | — | — | EP | disclosed |
| EP-0770132-A1 | STREPTOGRAMINES AND METHOD FOR PREPARING SAME BY MUTASYNTHESIS | Aventis Pharma S.A. (FR) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996001901-A1 | STREPTOGRAMINES AND METHOD FOR PREPARING SAME BY MUTASYNTHESIS | RHONE-POULENC RORER S.A. (FR) | 1996-01-25 | — | — | WO | disclosed |