Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.32 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.32 |
| ▸ | WNT3A | P56704 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.31 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.30 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2776562 | 0.84 | TDP1 (0.44) | ALDH1A1TSHR | |
| SCHEMBL15019261 | 0.82 | TSHR (0.40) | TSHR | |
| SCHEMBL18184676 | 0.78 | ATM (0.44) | CTNNB1WNT3AALDH1A1TSHR | |
| SCHEMBL20364682 | 0.78 | KDM4E (0.46) | HDAC6ALDH1A1HDAC3HDAC1HDAC2 | |
| SCHEMBL11595564 | 0.70 | HDAC6 (0.41) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL13080227 | 0.69 | HDAC6 (0.40) | HDAC6HDAC3HDAC1HDAC2HDAC8 | |
| SCHEMBL548652 | 0.68 | GRIA3 (0.54) | ALDH1A1HDAC3HDAC1GRIA3GRIA4 | |
| SCHEMBL31605579 | 0.68 | CHRNA7 (0.45) | HDAC6CTNNB1WNT3AALDH1A1TSHR | |
| SCHEMBL7325912 | 0.68 | CD40 (0.38) | ALDH1A1TSHR | |
| SCHEMBL11747762 | 0.67 | TTR (0.50) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010087980-A2 | BICYCLIC AMIDE DERIVATIVES FOR THE TREATMENT OF RESPIRATORY DEPRESSION | CORTEX PHARMACEUTICALS, INC. (US) | 2010-08-05 | — | — | WO | disclosed |
| EP-2187888-A2 | BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2010-05-26 | — | — | EP | disclosed |
| EP-2154970-A1 | DI-SUBSTITUTED AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2010-02-24 | — | — | EP | disclosed |
| WO-2009023126-A2 | BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2009-02-19 | — | — | WO | disclosed |
| WO-2008143963-A1 | DI-SUBSTITUTED AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES | CORTEX PHARMACEUTICALS, INC. (US) | 2008-11-27 | — | — | WO | disclosed |