Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGDS | O60760 | 7/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.37 |
| ▸ | POLQ | O75417 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.34 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | WNT3A | P56704 | 1/20 | 0.33 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14313078 | 0.93 | HPGDS (0.54) | HPGDSCSNK1DPOLQMAP4K4DGAT1 | |
| SCHEMBL14312941 | 0.92 | HPGDS (0.54) | HPGDSCSNK1DPOLQMAP4K4DGAT1 | |
| SCHEMBL3223201 | 0.87 | HPGDS (0.59) | HPGDSCSNK1DPOLQMAP4K4DGAT1 | |
| SCHEMBL3213889 | 0.86 | HPGDS (0.56) | HPGDSCSNK1DPOLQMAP4K4DGAT1 | |
| SCHEMBL3210065 | 0.86 | HPGDS (0.58) | HPGDSCSNK1DPOLQMAP4K4DGAT1 | |
| SCHEMBL2471757 | 0.84 | HPGDS (0.54) | HPGDSCSNK1DPOLQMAP4K4DGAT1 | |
| SCHEMBL3217764 | 0.84 | HPGDS (0.54) | HPGDSCSNK1DPOLQMAP4K4DGAT1 | |
| SCHEMBL12083963 | 0.83 | HPGDS (0.55) | HPGDSCSNK1DMAP4K4DGAT1CASP3 | |
| SCHEMBL3220698 | 0.82 | HPGDS (0.54) | HPGDSCSNK1DPOLQMAP4K4DGAT1 | |
| SCHEMBL3213787 | 0.81 | HPGDS (0.56) | HPGDSCSNK1DPOLQDGAT1WNT3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101646656-A | Pyrimidine hydrazide compounds as the PGDS inhibitor | SANOFI AVENTIS FR | 2010-02-10 | — | — | CN | claimed |
| CN-101646656-B | Pyrimidine hydrazide compounds as PGDS inhibitors | SANOFI AVENTIS SPA | 2013-08-14 | — | — | CN | disclosed |
| CN-101646656-A | Pyrimidine hydrazide compounds as the PGDS inhibitor | SANOFI AVENTIS FR | 2010-02-10 | — | — | CN | disclosed |