Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | PAK1 | Q13153 | 10/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27665869 | 0.84 | LMNA (0.52) | AKT2LMNAMAPTRPS6KB1HTT | |
| Hydrochloric Acid SCHEMBL28363987 | 0.83 | AKT2 (0.67) | AKT2LMNAMAPTRPS6KB1HTT | |
| Hydrochloric Acid SCHEMBL2799346 | 0.83 | AKT2 (0.67) | AKT2LMNAMAPTRPS6KB1HTT | |
| SCHEMBL27795231 | 0.79 | LMNA (0.54) | AKT2LMNAMAPTRPS6KB1HTT | |
| SCHEMBL2273815 | 0.75 | MAPT (0.61) | AKT2LMNAMAPTRPS6KB1HTT | |
| SCHEMBL5068467 | 0.72 | POLB (0.64) | AKT2MAPTPAK1 | |
| SCHEMBL29894717 | 0.72 | AKT2 (0.70) | AKT2LMNAMAPTRPS6KB1HTT | |
| SCHEMBL2279206 | 0.72 | AKT2 (0.70) | AKT2LMNAMAPTRPS6KB1HTT | |
| SCHEMBL27644898 | 0.69 | LMNA (0.60) | AKT2LMNAMAPTRPS6KB1HTT | |
| SCHEMBL4996432 | 0.69 | LMNA (0.68) | AKT2LMNAMAPTRPS6KB1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105106199-A | Methods of using MEK inhibitors | EXELIXIS INC | 2015-12-02 | — | — | CN | disclosed |
| CN-101605540-A | Methods of using MEK inhibitors | EXELIXIS INC (US) | 2009-12-16 | — | — | CN | disclosed |