Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 1/20 | 0.31 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14908805 | 0.89 | MEN1 (0.37) | KMT2AMEN1MAPK1GAABTK | |
| SCHEMBL27575292 | 0.85 | BTK (0.36) | KMT2AMEN1MAPK1GAABTK | |
| SCHEMBL1162997 | 0.84 | BTK (0.36) | KMT2AMEN1MAPK1GAABTK | |
| SCHEMBL28367798 | 0.83 | BTK (0.35) | KMT2AMEN1MAPK1GAABTK | |
| SCHEMBL512537 | 0.77 | RORC (0.37) | KMT2AMEN1MAPK1GAABTK | |
| Hydrochloric Acid SCHEMBL15285997 | 0.76 | RORC (0.37) | KMT2AMEN1MAPK1GAABTK | |
| SCHEMBL28269688 | 0.76 | KMT2A (0.36) | KMT2AMEN1MAPK1GAABTK | |
| SCHEMBL23268367 | 0.74 | KMT2A (0.35) | KMT2AMEN1MAPK1GAAKDM4E | |
| SCHEMBL391041 | 0.74 | KMT2A (0.43) | KMT2AMEN1MAPK1GAABTK | |
| SCHEMBL29069892 | 0.74 | BTK (0.31) | KMT2AMEN1MAPK1BTKCTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101861321-B | Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors | ASTRAZENECA AB | 2013-02-06 | — | — | CN | disclosed |
| CN-101861321-A | Pyrrolo [2, 3 -D] pyrimidin derivatives as protein kinase B inhibitors | ASTRAZENECA AB | 2010-10-13 | — | — | CN | disclosed |