Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Benzethonium. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 1.00 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 1.00 |
| ▸ | CHRM3 known ✓ | P20309 | 2/20 | 1.00 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 1.00 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 1.00 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 1.00 |
| ▸ | BDKRB2 known ✓ | P30411 | 1/20 | 0.98 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 1.00 |
| ▸ | MEN1 | O00255 | 5/20 | 1.00 |
| ▸ | KMT2A | Q03164 | 5/20 | 1.00 |
| ▸ | TP53 | P04637 | 4/20 | 1.00 |
| ▸ | HIF1A | Q16665 | 4/20 | 1.00 |
| ▸ | HTT | P42858 | 4/20 | 1.00 |
| ▸ | APAF1 | O14727 | 3/20 | 1.00 |
| ▸ | USP2 | O75604 | 3/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | RAD52 | P43351 | 3/20 | 1.00 |
| ▸ | LMNA | P02545 | 3/20 | 1.00 |
| ▸ | TSHR | P16473 | 3/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzethonium SCHEMBL21713 | 1.00 | SMN1; SMN2 (1.00) | SMN1; SMN2MEN1KMT2ATP53HIF1A | |
| Benzethonium SCHEMBL10341422 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2MEN1KMT2ATP53HIF1A | |
| Benzethonium SCHEMBL28210479 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2MEN1KMT2ATP53HIF1A | |
| Benzethonium SCHEMBL7271857 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2MEN1KMT2ATP53HIF1A | |
| Benzethonium SCHEMBL976363 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2MEN1KMT2ATP53HIF1A | |
| Benzethonium SCHEMBL13278583 | 0.99 | SMN1; SMN2 (0.98) | SMN1; SMN2MEN1KMT2ATP53HIF1A | |
| Benzethonium SCHEMBL122985 | 0.99 | SMN1; SMN2 (1.00) | SMN1; SMN2MEN1KMT2ATP53HIF1A | |
| Benzethonium SCHEMBL976365 | 0.98 | SMN1; SMN2 (0.96) | SMN1; SMN2MEN1KMT2ATP53HIF1A | |
| Benzethonium SCHEMBL1951703 | 0.98 | SMN1; SMN2 (0.98) | SMN1; SMN2MEN1KMT2ATP53HIF1A | |
| Benzethonium SCHEMBL5549294 | 0.98 | SMN1; SMN2 (0.98) | SMN1; SMN2MEN1KMT2ATP53HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110267658-A | Treatment of CNS disorders with sGC stimulators | 塞科里昂医疗股份有限公司 | 2019-09-20 | — | — | CN | disclosed |
| CN-109608545-A | The anti-HER4 antibody of same type specificity | 健泰科生物技术公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-106573971-A | anti-CD 20 glycoantibodies and uses thereof | 中央研究院 | 2017-04-19 | — | — | CN | disclosed |
| CN-102725310-A | Isoform specific anti-HER 4 antibodies | GENENTECH INC | 2012-10-10 | — | — | CN | disclosed |
| CN-101835803-A | Cysteine engineered anti-tenb2 antibodies and antibody drug conjugates | GENENTECH INC | 2010-09-15 | — | — | CN | disclosed |
| CN-101687037-A | Cysteine engineered anti-MUC 16 antibodies and antibody drug conjugates | GENENTECH INC | 2010-03-31 | — | — | CN | disclosed |