SCHEMBL27797948

SCHEMBL27797948

NCc1ccc(C(=O)NC2CC2)cc1NC(=O)c1ccc2cc[nH]c2c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 5/20 0.71
MAPK11 Q15759 4/20 0.71
SMYD3 Q9H7B4 5/20 0.66
CHRNA7 P36544 2/20 0.47
HTR3A P46098 1/20 0.47
KDM4E B2RXH2 1/20 0.45
ALDH1A1 P00352 1/20 0.45
HPGD P15428 1/20 0.45
ENPP2 Q13822 1/20 0.45
HSD17B10 Q99714 1/20 0.45
HDAC1 Q13547 4/20 0.43
HDAC3 O15379 3/20 0.43
HDAC2 Q92769 3/20 0.43
HDAC4 P56524 2/20 0.43
HDAC7 Q8WUI4 2/20 0.43
HDAC10 Q969S8 2/20 0.43
HDAC11 Q96DB2 2/20 0.43
HDAC8 Q9BY41 2/20 0.43
HDAC6 Q9UBN7 2/20 0.43
HDAC9 Q9UKV0 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1751245 0.83 MAPK14 (1.00) MAPK14MAPK11SMYD3CHRNA7
SCHEMBL28782872 0.80 MAPK14 (0.46) MAPK14MAPK11SMYD3KDM4E
SCHEMBL19710134 0.80 SMYD3 (0.72) MAPK14MAPK11SMYD3CHRNA7KDM4E
SCHEMBL21490165 0.80 SMYD3 (0.72) MAPK14MAPK11SMYD3CHRNA7KDM4E
SCHEMBL19710171 0.80 SMYD3 (1.00) MAPK14MAPK11SMYD3
SCHEMBL21489831 0.80 SMYD3 (1.00) MAPK14MAPK11SMYD3
SCHEMBL27776725 0.78 MAPK14 (0.74) MAPK14MAPK11SMYD3CHRNA7KDM4E
SCHEMBL6204355 0.78 MAPK14 (0.70) MAPK14MAPK11SMYD3CHRNA7HTR3A
SCHEMBL6204351 0.78 MAPK14 (0.70) MAPK14MAPK11SMYD3CHRNA7HTR3A
SCHEMBL24950457 0.77 SMYD3 (0.67) MAPK14MAPK11SMYD3CHRNA7HTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101616667-A Heterocyclic amide compounds useful as kinase inhibitors BRISTOL MYERS SQUIBB CO 2009-12-30 CN disclosed