Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 11/20 | 0.46 |
| ▸ | SMYD3 | Q9H7B4 | 7/20 | 0.42 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.40 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27797614 | 0.85 | MAPK11 (0.44) | MAPK14MAPK11SMYD3MAPK13MAPK12 | |
| SCHEMBL1752203 | 0.83 | MAPK11 (0.65) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL27797615 | 0.83 | ALDH1A1 (0.52) | MAPK14MAPK11MAPK13MAPK12 | |
| SCHEMBL27797760 | 0.82 | MAPK11 (0.53) | MAPK14MAPK11MAPK13MAPK12KDM4E | |
| SCHEMBL27797948 | 0.80 | MAPK14 (0.71) | MAPK14MAPK11SMYD3KDM4E | |
| SCHEMBL27797618 | 0.80 | MAPK11 (0.55) | MAPK14MAPK11SMYD3MAPK13MAPK12 | |
| SCHEMBL20521778 | 0.79 | SMYD3 (0.46) | SMYD3MEN1MAPTKMT2A | |
| SCHEMBL27776718 | 0.76 | MAPK11 (0.53) | MAPK14MAPK11SMYD3MAPK13MAPK12 | |
| SCHEMBL27776720 | 0.75 | MAPK14 (0.48) | MAPK14MAPK11MAPK13MAPK12KDM4E | |
| SCHEMBL27776723 | 0.74 | MAPK11 (0.49) | MAPK14MAPK11MAPK13MAPK12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101616667-A | Heterocyclic amide compounds useful as kinase inhibitors | BRISTOL MYERS SQUIBB CO | 2009-12-30 | — | — | CN | disclosed |