Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Terephthalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 3/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | SRD5A2 | P31213 | 2/20 | 0.50 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 3/20 | 0.48 |
| ▸ | CA2 | P00918 | 3/20 | 0.48 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA3 | P07451 | 1/20 | 0.48 |
| ▸ | TYR | P14679 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 1/20 | 0.48 |
| ▸ | CA4 | P22748 | 1/20 | 0.48 |
| ▸ | CA6 | P23280 | 1/20 | 0.48 |
| ▸ | CA5A | P35218 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4577544 | 0.86 | ALDH1A1 (0.59) | MAPTALDH1A1TSHRTP53HTT | |
| Terephthalic Acid SCHEMBL28926617 | 0.86 | MAPT (0.57) | MAPTALDH1A1TSHRTP53HTT | |
| SCHEMBL9234376 | 0.86 | ALDH1A1 (0.59) | MAPTALDH1A1TSHRTP53HTT | |
| Hydrochloric Acid SCHEMBL9192168 | 0.84 | ALDH1A1 (0.57) | MAPTALDH1A1TSHRTP53HTT | |
| SCHEMBL19412971 | 0.84 | MAPT (0.56) | MAPTALDH1A1TSHRTP53HTT | |
| Terephthalic Acid SCHEMBL2160594 | 0.83 | TSHR (0.60) | MAPTALDH1A1TSHRTP53HTT | |
| Terephthalic Acid SCHEMBL11564620 | 0.83 | TSHR (0.60) | MAPTALDH1A1TSHRTP53HTT | |
| Isophthalic Acid SCHEMBL1790335 | 0.83 | KMT2A (0.50) | MAPTALDH1A1KMT2ACA1CA2 | |
| SCHEMBL9144768 | 0.82 | ALDH1A1 (0.55) | MAPTALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL11527703 | 0.82 | ALDH1A1 (0.55) | MAPTALDH1A1HTTSMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101681140-B | Electrically conductive roller | BRIDGESTONE CORP | 2012-08-22 | — | — | CN | disclosed |
| CN-101681140-A | electrically conductive roller | BRIDGESTONE CORP | 2010-03-24 | — | — | CN | disclosed |