Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.52 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.41 |
| ▸ | KIF11 | P52732 | 5/20 | 0.39 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.36 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.36 |
| ▸ | SMURF2 | Q9HAU4 | 1/20 | 0.35 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1686549 | 0.90 | TRPV1 (0.59) | TRPV1DUSP3KIF11CYP11B2CYP11B1 | |
| SCHEMBL1686447 | 0.80 | TRPV1 (0.61) | TRPV1KIF11CYP11B2CYP11B1 | |
| SCHEMBL1686401 | 0.76 | TRPV1 (0.59) | TRPV1DUSP3KIF11ALOX5ALOX5AP | |
| SCHEMBL766496 | 0.76 | TRPV1 (0.55) | TRPV1KIF11CYP11B2CYP11B1 | |
| SCHEMBL766679 | 0.74 | TRPV1 (0.69) | TRPV1DUSP3KIF11ALOX5ALOX5AP | |
| SCHEMBL1686325 | 0.74 | TRPV1 (0.76) | TRPV1KIF11 | |
| SCHEMBL1686553 | 0.74 | TRPV1 (0.62) | TRPV1KIF11CYP11B2CYP11B1 | |
| SCHEMBL1686321 | 0.74 | TRPV1 (0.76) | TRPV1KIF11 | |
| SCHEMBL1686303 | 0.72 | TRPV1 (0.82) | TRPV1 | |
| SCHEMBL18662474 | 0.72 | TRPV1 (0.52) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211927-B2 | 5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators | MSD, Oss B.V. (NL) | 2012-07-03 | — | — | US | disclosed |
| EP-2185530-A1 | 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. Organon (NL) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016241-A1 | 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. ORGANON (NL) | 2009-02-05 | — | — | WO | disclosed |