Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 5/20 | 0.59 |
| ▸ | KIF11 | P52732 | 8/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | SMURF2 | Q9HAU4 | 1/20 | 0.40 |
| ▸ | SMURF1 | Q9HCE7 | 1/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.40 |
| ▸ | RARA | P10276 | 1/20 | 0.39 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | RARG | P13631 | 1/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2779934 | 0.90 | TRPV1 (0.52) | TRPV1KIF11DUSP3CYP11B1CYP11B2 | |
| SCHEMBL1686447 | 0.89 | TRPV1 (0.61) | TRPV1KIF11CYP11B1CYP11B2P2RX7 | |
| SCHEMBL1686401 | 0.85 | TRPV1 (0.59) | TRPV1KIF11DUSP3 | |
| SCHEMBL766496 | 0.84 | TRPV1 (0.55) | TRPV1KIF11CYP11B1CYP11B2P2RX7 | |
| SCHEMBL766679 | 0.82 | TRPV1 (0.69) | TRPV1KIF11DUSP3FFAR1RARA | |
| SCHEMBL1686325 | 0.82 | TRPV1 (0.76) | TRPV1KIF11P2RX7 | |
| SCHEMBL1686553 | 0.82 | TRPV1 (0.62) | TRPV1KIF11CYP11B1CYP11B2P2RX7 | |
| SCHEMBL1686321 | 0.82 | TRPV1 (0.76) | TRPV1KIF11P2RX7 | |
| SCHEMBL1686303 | 0.80 | TRPV1 (0.82) | TRPV1 | |
| SCHEMBL18662474 | 0.80 | TRPV1 (0.52) | TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211927-B2 | 5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators | MSD, Oss B.V. (NL) | 2012-07-03 | — | — | US | disclosed |
| EP-2185530-B1 | 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | ORGANON NV (NL) | 2011-09-14 | — | — | EP | disclosed |
| US-20110065764-A1 | 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. Organon and Pharmacopeia, LLC (NL) | 2011-03-17 | — | — | US | disclosed |
| CN-101796036-A | 5-Phenylisoxazole-3-carboxamide derivatives as TRPV1 modulators | ORGANON NV | 2010-08-04 | — | — | CN | disclosed |
| EP-2185530-A1 | 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. Organon (NL) | 2010-05-19 | — | — | EP | disclosed |
| WO-2009016241-A1 | 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. ORGANON (NL) | 2009-02-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065764-A1 | 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | TRPV1, TRPV5, TRPV3 | TRPV1 1/4885KIF11 3495/4885DUSP3 2145/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.