Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 4/20 | 0.80 |
| ▸ | CNR1 | P21554 | 2/20 | 0.80 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | BCHE | P06276 | 1/20 | 0.54 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.54 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.52 |
| ▸ | GUCY1B2 | O75343 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.52 |
| ▸ | HTR1A | P08908 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | DRD1 | P21728 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.52 |
| ▸ | GUCY1A2 | P33402 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2760339 | 0.89 | CNR2 (0.70) | CNR2CNR1ACHEBCHEPTGER4 | |
| SCHEMBL9917500 | 0.89 | CNR2 (1.00) | CNR2CNR1ACHEBCHEPTGER4 | |
| SCHEMBL516738 | 0.85 | CNR2 (0.67) | CNR2CNR1ACHEBCHEPTGER4 | |
| SCHEMBL19793130 | 0.84 | CNR2 (0.66) | CNR2CNR1ACHEBCHEPTGER4 | |
| SCHEMBL30415447 | 0.84 | CNR2 (0.66) | CNR2CNR1ACHEBCHEPTGER4 | |
| SCHEMBL516208 | 0.84 | CNR2 (0.66) | CNR2CNR1ACHEBCHEPTGER4 | |
| SCHEMBL16122909 | 0.84 | CNR2 (0.66) | CNR2CNR1ACHEBCHEPTGER4 | |
| SCHEMBL927918 | 0.83 | CNR1 (0.64) | CNR2CNR1ACHEPTGER4P2RX4 | |
| SCHEMBL17508619 | 0.82 | CNR2 (0.63) | CNR2CNR1ACHEBCHEPTGER4 | |
| SCHEMBL12327729 | 0.81 | CNR2 (0.62) | CNR2CNR1ACHEBCHEPTGER4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101965337-B | Novel 1-benzil-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 | ACRAF | 2013-11-06 | — | — | CN | disclosed |
| CN-101965337-A | Novel 1-benzil-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 | ACRAF | 2011-02-02 | — | — | CN | disclosed |
| CN-101952256-A | Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of MCP-1, CX3CR1 and p40 | ACRAF | 2011-01-19 | — | — | CN | disclosed |
| CN-101945855-A | Novel 1-benzyl-3-hydroxymethylindazole derivatives and use thereof in the treatment of diseases based on the expression of mcp-1, cx3cr1 and p40 | ACRAF | 2011-01-12 | — | — | CN | disclosed |