Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 2/20 | 0.36 |
| ▸ | CA1 | P00915 | 2/20 | 0.36 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | CA9 | Q16790 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | BACE1 | P56817 | 4/20 | 0.35 |
| ▸ | REN | P00797 | 1/20 | 0.35 |
| ▸ | CTSD | P07339 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4312620 | 0.93 | BACE1 (0.37) | ALDH1A1MEN1KMT2AMAPTBACE1 | |
| SCHEMBL4312471 | 0.89 | BACE1 (0.40) | GRM5MAPTARBACE1REN | |
| SCHEMBL4306001 | 0.89 | GRM5 (0.37) | ALDH1A1GRM5MEN1KMT2AMAPT | |
| SCHEMBL13932862 | 0.88 | ALDH1A1 (0.38) | ALDH1A1MEN1KMT2AMAPTLMNA | |
| SCHEMBL4319022 | 0.86 | GRM5 (0.44) | ALDH1A1GRM5CA12CA1CA2 | |
| SCHEMBL4309762 | 0.84 | BACE1 (0.38) | ALDH1A1GRM5MEN1KMT2AMAPT | |
| SCHEMBL27801226 | 0.81 | FFAR1 (0.42) | GRM5MEN1KMT2AARBACE1 | |
| SCHEMBL23190460 | 0.81 | BACE1 (0.34) | ALDH1A1MEN1KMT2AMAPTBACE1 | |
| SCHEMBL4313333 | 0.81 | BACE1 (0.38) | BACE1RENCTSDCYP3A4BACE2 | |
| SCHEMBL23190454 | 0.80 | BACE1 (0.35) | ALDH1A1GRM5MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101641335-A | Amino-5-[substituted-4-(difluoromethoxy)phenyl]-5- phenylimidazolone compounds as ss-secretase inhibitors | WYETH CORP US | 2010-02-03 | — | — | CN | disclosed |