Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 11/20 | 0.58 |
| ▸ | MAP2K2 | P36507 | 6/20 | 0.58 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 4/20 | 0.46 |
| ▸ | TNFRSF1A | P19438 | 4/20 | 0.46 |
| ▸ | MAP3K9 | P80192 | 3/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | CTSV | O60911 | 1/20 | 0.45 |
| ▸ | CTSL | P07711 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | SRC | P12931 | 3/20 | 0.45 |
| ▸ | PRKCB | P05771 | 1/20 | 0.45 |
| ▸ | STK3 | Q13188 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | LCK | P06239 | 2/20 | 0.43 |
| ▸ | CLK1 | P49759 | 2/20 | 0.43 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.43 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27780724 | 0.87 | MAP2K1 (0.46) | MAP2K1MAP2K2IDO1MAPT | |
| SCHEMBL6035244 | 0.85 | CTSV (0.60) | MAP2K1MAP2K2IDO1CTSVCTSL | |
| SCHEMBL1340714 | 0.82 | MAP2K1 (0.64) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL1488391 | 0.77 | MAP2K1 (0.71) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL4860159 | 0.77 | MAP2K1 (0.75) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL27693106 | 0.77 | MAP2K1 (0.60) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL27801998 | 0.76 | MAP2K1 (0.55) | MAP2K1MAP2K2IDO1AURKATNFRSF1A | |
| SCHEMBL1340491 | 0.75 | MAP2K1 (0.57) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL188505 | 0.74 | MAP2K1 (1.00) | MAP2K1MAP2K2IDO1 | |
| SCHEMBL30505247 | 0.74 | MAP2K1 (1.00) | MAP2K1MAP2K2IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101663279-A | inhibitors of mek | ARDEA BIOSCIENCES INC (US) | 2010-03-03 | — | — | CN | disclosed |